The Association between Pre-pregnancy Obesity and Weight Gain in Pregnancy, with Growth Deviations in Newborns.

INTRODUCTION obesity in pregnancy has been associated with increased morbidity for the mother and fetus. OBJECTIVE to quantify the association between obesity in pregnancy with growth deviations of their newborn infants. METHODS a study of non-matched cases and controls was performed based on the Nuevo Civil Hospital of Guadalajara "Dr. Juan I Menchaca" 2012-2013. The dependent variables were the newborn being either large (LGA) or small for gestational age (SGA), and the independent variable was pre-pregnancy obesity. Gynecoobstetric and socioeconomic data were collected. The association between the dependent and independent variables was assessed with logistic regression. RESULTS one-hundred and forty-three mother-child dyads were studied with growth deviations of their newborn infants, and 137 mother-child dyads without growth deviations were studied. The age of the patients was 24.7 ± 6.3 vs. 24.0 ± 6.0 years, and the gestational age was 38 ± 1.2 vs. 38 ± 1.5. Factors associated with growth deviations were pre-pregnancy obesity (OR 2.65, 95% CI 1.29- 5.44), elevated weight gain during pregnancy (OR 1.98, 95% CI 1.04-3.76) and disease during pregnancy (OR 2.62, 95% CI 1.05-6.76). A multivariate model with the dependent variable LGA and associated covariates showed that pre-pregnancy obesity and high gestational weight gain were predictors of LGA (OR 2.43, 95% CI 1.10-5.40) and (OR 3.31, 95% CI 1.83-5.96). CONCLUSIONS in a population of young women with scarce economic resources, pre-pregnancy obesity and high weight gain during pregnancy were predictors of LGA.